Endocrine Abstracts

Introduction: Glucocorticoids, even endogenous or exogenous, suppress the inflammatory response therefore they are the most preferred treatment options in inflammatory diseases. Persistent hypercortisolism induces lymphopenia and lymphoid tissue atrophy. Excessive endogenous hypercortisolism might mask the active inflammatory disease. Rebound immune modulation may occur after Cushing’s syndrome (CS) remission, leading to the new onset of autoimmune diseases.<p class="...

Introduction: Lymphocytic hypophysitis is a rare endocrine disease involving lymphocytic infiltration and chronic pituitary inflammation. It may result in significant morbidity by loss of pituitary functions and neurological deficits. Pituitary abscess is another rare disease which may be associated with underlying parasellar pathology. Here, we report a case of lymphocytic hypophysitis diagnosed with a pituitary abscess and recurrent suprasellar involvement after surgery....

Introduction: ‘Atypia of undetermined significance/follicular lesion of undetermined significance’ (AUS/FLUS) is a heterogeneous diagnostic thyroid fine needle aspiration biopsy (FNAB) category. AUS/FLUS is comprised of cases that cannot be definitively diagnosed as benign, suspicious for/consistent with neoplasm, suspicious for malignancy or malignant. The recommended management strategy for these cases is to perform a repeat FNAB after an appropriate time course. A...

Objective: Insulin insufficiency which is the result of deficiency of β-cells is the common feature for all types of diabetes. Therefore protection of functional β-cell mass is the keystone of diabetes treatment. Betatrophin, a newly determined hormone, has been identified as a potent stimulator that increases the production and expansion of β-cells in mice. However, very little is known about the physiological role of betatrophin in h...